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Mercedes C.•14 hours ago

Getting an Infection during the period of "Morning Sickness", poses Higher Risks of Congenital Heart Disease?

One of the most unexpected parts of the conversation was Jimmy Carr’s discussion of morning sickness. 🫣

It sent me down a rabbit hole because there is an interesting evolutionary theory behind why morning sickness tends to occur during this particular period of pregnancy.

The Maternal and Embryo Protection Hypothesis, an evolutionary theory about morning sickness, where:

  1. Organogenesis: Morning sickness typically peaks between weeks 6 and 14 of pregnancy. When the embryo’s major organs (including the heart, brain, and limbs) are forming and are most vulnerable to damage from toxins or pathogens.

  2. The "Shield" Effect: Because pregnancy naturally suppresses a woman's immune system (to prevent her body from rejecting the fetus), she becomes more sensitive to foodborne pathogens. Evolutionary biologists believe nausea and vomiting evolved to force mothers to avoid or expel potentially toxic or bacteria-laden foods during this window.

  3. The Shift: Once the organs are fully formed (around the second trimester) and the baby enters the growth-only phase, morning sickness usually stops for most women.

EVIDENCE for Infection & Congenital Heart Disease ﮩ٨ـﮩﮩ٨ـ🫀ﮩ٨ـﮩﮩ٨ـ

A link from two meta-analyses, between First Trimester Maternal Infections and Fetal Congenital Heart Defects has been found, especially in regards to rubella virus, coxsackievirus, respiratory infections, and influenza.

⚠️ Though there is an important distinction here to make:

This does NOT mean that morning sickness itself is linked to congenital heart defects.

But the same period of pregnancy in which morning sickness may have evolved to reduce exposure to potentially harmful substances is also a period when the developing embryo is particularly vulnerable to certain environmental insults, including infections.

Mercedes C.•14 hours ago
Podcasts We Lovewhat now with trevor noah

Its a meeting of 2 comedy greats: Jimmy Carr and Trevor Noah. 🎭

Just listened to Trevor Noah’s conversation with Jimmy Carr. It was such a riveting conversation traversing AI, comedy, psychology, mortality, relationships, economics, technology, community, ideology and more.

What Now? With Trevor Noah - Jimmy Carr: Convenience is Stealing Your Life

Jimmy Carr: Convenience is Stealing Your Life

Both Trevor and Jimmy are incredibly well-read, and I’ve always found their takes, be it controversial or unconventional, pretty interesting, and they may be right or they might just be wrong. This long-form conversation between them was quite fascinating indeed, and here are some I'd thought I'd share:

Jimmy starts off introducing the concept of Mankind's Three Humiliations 📜

  1. Copernicus: Earth isn't the centre of the universe. > "We are not the centre of the universe."

  2. Darwin: Humans evolved from animals, and are biologically in the category of animals > "We are just the same as other animals."

  3. Freud: Our conscious mind isn't fully in control of ourselves. > "Our subconscious and actions aren't really under our control"

He then shares his take of AI being the the upcoming Fourth Humiliation, where we, as humans, can no longer claim to be the smartest being in the room.

He later mentions in regards to AI dependence - “Don't outsource any skill you're not comfortable losing” .🚨

I think its truly a thought worth pondering on. 💡 Convenience has a hidden cost: when we can outsource it, the skill itself can become unnecessary. And once a skill becomes unnecessary, there may be little incentive to maintain it. Then, one day, we just lose it.

They also had conversations on economics, tax, society, which linked to an interesting circle of thought:

Asking how would you define a revolution? And are we in one now?

In the podcast, Jimmy defines a revolution as the replacement of elites.

  • And the first signs of that is the masses no longer trusting institutions,

  • Which lead to conspiracy theories

He also mentions that:

We can live without truth pretty easily. But we can't live without trust. But we need truth to make trust.

👀 But where do we go from there? 🧐 Which ones would you agree with?

Definitely one of those conversations that made me pause and rethink many things. 💭

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