Summary
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1 Sample Definition And Size
Nine studies involving 110 obese patients without clinically overt heart failure were included in the meta-analysis. Six studies tested dietary interventions, and three tested bariatric surgery.
2 Study Type
Systematic review and meta-analysis of observational studies.
3 Conflicts Of Interest
The authors declared no conflicts of interest.
4 Results Summary
Therapeutic weight loss in obese patients without heart failure was associated with significant reductions in heart rate (-9 beats/min, 95% CI: -12 to -6; p < 0.001), mean arterial pressure (-7 mm Hg, 95% CI: -11 to -3; p < 0.001), and resting oxygen consumption (-85 ml/min, 95% CI: -111 to -60; p < 0.001). Central cardiac hemodynamics improved, with reductions in pulmonary capillary wedge pressure (-3 mm Hg, 95% CI: -5 to -1; p < 0.001) and mean pulmonary artery pressure (-5 mm Hg, 95% CI: -8 to -2; p = 0.001). Exercise hemodynamics showed a significant reduction in exercise pulmonary artery pressure (p = 0.02).